T3 - Liothyronine sodium -
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Pharmaceutical Name: T3 ( Uni- Pharma Laboratory )
Chemical name: Liothyronine sodium
Chem . Abstr . Name: sodium (2S)-2-amino-3-[4 - (4-hydroxy-3-iodophenoxy) -3,5-diiodophenyl] propanoate
Molecular Structure: C15H11I3NNaO4
Molecular Weight: 672.96 gr / mol
Liothyronine is the most potent form of thyroid hormone. As such, it acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. The thyroid hormones are essential to proper development and differentiation of all cells of the human body. These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
In comparison to levothyroxine (T4), liothyronine has a faster onset of action as well as a shorter biological half-life, which may be due to less plasma protein biding to thyroxine-binding globulin and transthyretin.
Thyroid hormones enhance oxygen consumption by most tissues of the body and increase the basal metabolic rate and the metabolism of carbohydrates, lipids and proteins. In vitro studies indicate that T3 increases aerobic mitochondrial function, thereby increasing the rates of synthesis and utilization of myocardial high-energy phosphates. This, in turn, stimulates myosin ATPase and reduces tissue lactic acidosis. Thus, thyroid hormones exert a profound influence on virtually every organ system in the body and are of particular importance in the development of the central nervous system.
While the source of levothyroxine (T4) and some triiodothyronine (T3) is via secretion from the thyroid gland, it is now well-established that approximately 80% of circulating T3 arises predominantly by way of the extrathyroidal conversion of T4. The membrane - bound enzyme Responsible for this reaction is iodothyronine 5'- deiodinase . Activity of the enzyme is greatest in the liver and kidney. A second pathway of T4 to T3 conversion occurs via a PTU-insensitive 5'-deiodinase located primarily in the pituitary and central nervous system.
1 box contains 30 tablets with 25 mg / each