Semaglutide is a potent once-weekly GLP-1 RA, significantly reducing
HbA1c, body weight and systolic blood pressure. However, it is associated with
increased incidence of gastrointestinal adverse events. Results for
pancreatitis and retinopathy require further assessment in post-approval
pharmacovigilance studies.
Semaglutide belongs to a class of medications known as glucagon-like
peptide-1 receptor agonists, or GLP-1 RAs. It mimics the GLP-1 hormone,
released in the gut in response to eating.
One role of GLP-1 is to prompt the body to produce more insulin, which
reduces blood sugar (glucose). For that reason, Semaglutide used for more than
15 years to treat Type 2 diabetes.
But GLP-1 in higher amounts also interacts with the parts of the brain
that suppress your appetite and signal you to feel full. When used in
conjunction with diet and exercise, it can cause significant weight loss — and
a reduced risk of cancer, diabetes and heart disease — in people who are obese
or overweight.
The side effects of semaglutide are typically mild — especially when
compared to the complications associated with overweight and obesity.
People taking semaglutide for weight loss may experience:
Dizziness
Fatigue
Gastrointestinal issues, such as diarrhea, constipation and gassiness
Headache
Stomach issues, including nausea, vomiting, pain or distension (bloat)
Gastrointestinal issues are the most common complaint among people just
starting semaglutide. But you may be able to reduce the side effects by
beginning on a lower dose and then slowly increasing the amount you take.
