Oxymetholone (also known as anapolon or anadrol) is a very drastic
synthetic steroid, 17-alpha-alkylated modification of dihydrotestosterone. It
was developed for the treatment of osteoporosis and anaemia, as well as to
stimulate muscle gain in malnourished and debilitated patients. Oxymetholone
has been approved by the American Food and Drug Administration (FDA) for use in
humans. Later there where created non-steroidal drugs that effectively could
treat anaemia and osteoporosis; because of this anapolon lost his popularity
and by 1993 Syntex decided to cease the production of the drug, as well as
other manufacturers did.
By its performance parameters oxymetholone is most
similar to methandienone. As with methandienone, it provokes not only active
muscle bulking, but also a significant increase in power performance. However,
a large part of the gained weight is because of water retention in the body,
which can lead to high blood pressure on cycle.
Thanks to its ability to influence the level of
hemoglobin and to increase the blood volume in the body, oxymetholone may cause
an extremely strong pumping effect by athletes, which consequently complicates
the training process, because muscles get sore almost immediately after the
first heavy set.
Oxymetholone is a derivative of
dihydrotestosterone, which gives it a chemical structure that does not
aromatize. Despite the fact that oxymetholone does not directly convert to
estradiol, it itself has pronounced estrogenic properties. It should be
remembered that because of this peculiarity only antiestrogens would be able to
combat with estrogenic side effects, but not aromatase inhibitors, because
aromatase is not involved into the process.
Some suggest that oxymetholone`s estrogenic
activity relates to the progestogenic one, like with nandrolones. Side effects
may be similar. However, medical studies have shown that oxymetholone does not
possess any progestogenic activity.
Pharmacom Labs managed to create the injectable
version of this steroid. Thanks to the missing first pass through the liver it
shows higher bioavailability (= efficiency) and lower hepatoxity as compared
against the oral version.
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