Growth Hormone Releasing Peptide-6 (GHRP-6) is a synthetic hexapeptide,
which specifically stimulates secretion of growth hormone by pituitary
somatotrophs. Somatotrophs are cells in the anterior pituitary that release
pituitary growth hormone.
GHRP-6 is one of many synthetic met-enkephalin
analogues that include unnatural D-amino acides and was developed for its
growth hormone-releasing activity
Usage
GHRP-6 stimulates growth hormone secretion, the
increase of growth hormone levels can decrease body fat, increase muscle mass,
and increase strength and stamina.
The release of growth hormones stimulated by
GHRP-6 signals the liver to secrete an anabolic hormone specifically the
Insulin-like Growth Factor (IGF-1), which has also been implicated in improving
the body’s ability to burn fat and build muscle.
GHRP-6 is widely used by fitness professionals for
pronounced muscle gains and decreased healing and recovery time.
Mechanism of Action
The sequence of GHRP-6, which contains six amino
acids, notifies the human brain to release growth hormones from the pituitary
gland while obstructing the release of Somatostatin, which is a peptide hormone
that regulates the endocrine system. This then signals the liver to secrete an
anabolic hormone, the Insulin-like Growth Factor (IGF-1).
GHRP-6 initiates a ghrelin mimetic response, which
stimulates the ghrelin receptors of the body. The ghrelin receptors enable the
brain to send a signal to the pituitary gland to secrete the growth hormone.
The secreted growth hormone then assists the liver to release IGF-1.
