Sermorelin is a synthetically made version of growth hormone releasing hormone (GHRH), the endogenous hormone responsible for stimulating natural growth hormone production. Also known as growth hormone releasing factor and GRF 1-29, it is categorized as a growth hormone secretagogue, a compound which stimulates increased secretion of growth hormone from the pituitary gland.
Usage
Sermorelin stimulates growth hormone production,
thereby increasing muscle mass, decreasing body fat, enhancing recovery, improving
sleep, enhancing flexibility and joint health, and improving overall health and
wellness.
Sermorelin is used to treat poor growth
development (typically in children) due to growth hormone deficiency. It
functions by stimulating the pituitary gland to release more natural growth
hormone.
Mechanism of Action
Similarly to the body’s natural GHRH, Sermorelin
works by attaching to the growth hormone releasing hormone receptor (or GHRHr)
in the anterior part of the pituitary gland. There, it works to stimulate the
production of growth hormone and begins inducing increases in production of
endogenous IGF-1. As it functions in similar manner to GHRH, Sermorelin’s
positive effect on growth hormone output is modulated by a negative feedback
mechanism initiated by somatostatin, the endogenous hormone also known as
growth hormone inhibiting hormone (GHIH). This initiates many positive effects,
some of which are the prevention of extreme, unhealthy growth hormone levels in
the body and the mirroring of more natural patterns of fluctuation in growth
hormone concentrations.
Sermorelin’s natural action mechanism allows for
the preservation of the hypothalamic-pituitary-somatotropic axis, preventing
the shutdown of hormone production that typically accompanies direct replacement
with hGH. Sermorelin has also been shown to improve sleep quality, enhancing
the duration of restorative slow wave sleep and amplifying sleep-related
secretion of growth hormone while reducing production of cortisol (a catabolic
stress hormone).
Administration
Mode of Administration: Subcutaneous injection to
a fleshy part of the body, typically to the stomach or abdominal area.
Before administering Sermorelin, always be sure to
use a clean and sterile syringe.
Hold the Sermorelin vial upright and insert the
syringe in the center of the cap.
Draw the plunger until you have the correct amount
(see ‘Dosage’ below) in the syringe and carefully remove it.
Before administering the syringe, use alcohol to
cleanse the area of skin.
Pinch the skin around the area to be injected,
leave about 2 cm on each side.
Hold the syringe at a 90 degree angle to your skin
and swiftly insert the syringe.
Depress the plunger fully, until the syringe is
empty, and carefully draw out.
Dosage
Dosage Amount: 100mcg to 1000mcg (0.10mg to 1.0mg)
Dosage Frequency: 1 - 3 times daily
Sermorelin can either administered once daily
before bed or split into 2 – 3 smaller doses throughout the day. Both
approaches to administration can be effective and have been shown to have positive
results in clinical studies.
While Sermorelin has a relatively short half-life
of up to 20 minutes, it has been shown to stimulate an acute release of growth
hormone for two hours after administration. Protocols delivering three daily
doses of as little as 100mcg (0.10mg) per administration have been shown to
cause a significant increase in growth hormone and IGF-1 secretion.
- Stock: 2 - 3 Days
